One oral doses of sildenafil up to a hundred mg produced no clinically relevant modifications while in the ECGs of regular male volunteers.
Blood pressure level was measured immediately after administration of VIAGRA at precisely the same periods as Individuals specified for the initial doxazosin study. There were two topics who had a standing SBP of < eighty five mmHg. In these two topics, hypotension was documented to be a moderately serious adverse function, beginning at somewhere around one hour right after administration of VIAGRA 50 mg and resolving soon after close to 7.
Dette legemidlet kan i enkelte tilfeller forårsake bivirkninger, Guys det er kun en liten andel av brukerne som vil oppleve det. De rapporterte bivirkningene er som oftest svært milde, og forekommer normalt bare i en kortere periode.
NO then activates the enzyme guanylate cyclase, which leads to improved amounts of cyclic guanosine monophosphate (cGMP), generating smooth muscle peace inside the corpus cavernosum and permitting inflow of blood.
Snakk med lege før du tar legemidlet dersom du har høyt blodtrykk som ikke er godt behandlet, eller har uregelmessige hjerteslag/hjertebank.
Nonetheless, there aren't any controlled medical info on the safety or efficacy of VIAGRA in people with sickle cell or linked anemias.
Viagra is meant for use in Gentlemen, and it is not likely to be used in Ladies who are pregnant or breastfeeding. Even so, Viagra is not really envisioned to generally be harmful to the fetus.
Protection of combined usage of PDE5 inhibitors and alpha-blockers might be impacted by other variables, such as intravascular quantity depletion and various anti-hypertensive medications.
Know the medicines you are taking. Hold a list of them to show on your Health care service provider and pharmacist once you have a new drugs.
Pregnancy. It is far from acknowledged if or how sildenafil could impact pregnancy or damage an unborn baby. Tell your healthcare company Should you be or strategy to become Expecting.
Sildenafil is really a strong and selective inhibitor of cGMP-specific more info phosphodiesterase variety five (PDE5), that is liable for degradation of cGMP within the corpus cavernosum. The molecular framework of sildenafil is similar to that of cGMP and acts for a competitive binding agent of PDE5 in the corpus cavernosum, resulting in extra cGMP and greater penile reaction to sexual stimulation.
You can find a possible for cardiac hazard of sexual exercise in people with preexisting heart problems. As a result, remedies for erectile dysfunction, together with VIAGRA, shouldn't be generally Utilized in Adult males for whom sexual activity is inadvisable thanks to their underlying cardiovascular status.
This Individual Info leaflet summarizes the most important specifics of VIAGRA. If you want to more info, talk with your healthcare company. You are able to question your Health care service provider or pharmacist for information about VIAGRA that is certainly penned for well being pros.
In the event you unintentionally take far too much VIAGRA, get in touch with your doctor or visit the closest hospital crisis room straight away.